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Immobilized photosensitizers for antimicrobial applications

Paper ID Volume ID Publish Year Pages File Format Full-Text
30022 44454 2015 20 PDF Available
Title
Immobilized photosensitizers for antimicrobial applications
Abstract

•Photodynamic antimicrobial chemotherapy (PACT) can be used to kill microorganisms.•PACT involves a photosensitizer, visible light and oxygen for the bacterial killing.•Photosensitizers have been immobilized on solid supports for PACT applications.•Solid supports described herein include polymers, silica beads and nanotubes.•Immobilized photosensitizers can be reused for an eco friendly approach.

Photodynamic antimicrobial chemotherapy (PACT) is a very promising alternative to conventional antibiotics for the efficient inactivation of pathogenic microorganisms; this is due to the fact that it is virtually impossible for resistant strains to develop due to the mode of action employed. PACT employs a photosensitizer, which preferentially associates with the microorganism, and is then activated with non-thermal visible light of appropriate wavelength(s) to generate high localized concentrations of reactive oxygen species (ROS), inactivating the microorganism.The concept of using photosensitizers immobilized on a surface for this purpose is intended to address a range of economic, ecological and public health issues.Photosensitising molecules that have been immobilized on solid support for PACT applications are described herein. Different supports have been analyzed as well as the target microorganism and the effectiveness of particular combinations of support and photosensitizer.

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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 150, September 2015, Pages 11–30
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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