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The 4-hydroxyestrone: Electron emission, formation of secondary metabolites and mechanisms of carcinogenesis

Paper ID Volume ID Publish Year Pages File Format Full-Text
30033 44456 2010 5 PDF Available
Title
The 4-hydroxyestrone: Electron emission, formation of secondary metabolites and mechanisms of carcinogenesis
Abstract

4-Hydroxyestrone (4-OHE1), a typical cancer-inducing metabolite, originating from 17β-estradiol (17β-E2), was chosen as a model for the studies. The aim was to get a deeper insight in the mechanisms of its ability to initiate cancer. It was found, that 4-OHE1 can eject electrons (eaq-), when excited in the singlet state by monochromatic UV-light (λ = 254 nm) in polar media (water:ethanol = 40:60 vol.%). The quantum yield Q(eaq-), determined for various 4-OHE1 concentrations, is found to be as high as that previously observed for 17β-E2. It decreases with increasing substrate concentration, but it is enhanced at higher temperature. The ability of 4-OHE1 to eject as well as to consume and to transfer electrons to other biological systems, classifies it as an electron mediator, similar to 17β-E2.The 4-OHE1 transients resulting of the electron emission process are leading to the formation of secondary metabolites. Surprisingly, it was established that the secondary metabolites possess likewise the ability to eject as well as to consume electrons. Hence, they behave similar like 17β-E2. However, the structure of the secondary formed metabolites, which determinates their biological properties and carcinogenity, depends on the nature of the available reaction partners involved in their formation. A probable reaction mechanism explaining the subject matter is discussed.

Keywords
4-Hydroxyestrone (4-OHE1); Electron emission from 4-OHE1; Secondary metabolites; Reaction mechanisms of carcinogenity
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 98, Issue 1, 21 January 2010, Pages 20–24
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
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