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From green to red – To more dead? Autofluorescent proteins as photosensitizers

Paper ID Volume ID Publish Year Pages File Format Full-Text
30043 44456 2010 4 PDF Available
Title
From green to red – To more dead? Autofluorescent proteins as photosensitizers
Abstract

Inactive compounds like autofluorescent proteins can absorb visible daylight (around 500–700 nm) and can emit active electrons producing reactive oxygen species (ROS) leading to an increase in photokilling processes in bacteria. The endogenously originated ROS create single strand breaks in the cells DNA. These various types of breaks can be partially repaired by different cellular repair systems but a high number of breaks leads to cell death. A dramatic increase in cell killing can be observed from green, via yellow to red color emission. This was tested by colony forming ability. The generation of ROS and the bacterial protection mechanisms are discussed. We outline some possibilities for use the protein’s properties for treatment of antibiotic multi-resistant and difficult to treat bacteria like the methicillin-resistant Staphylococcus aureus (MRSA).

Keywords
Carrier molecules; Fluorescent proteins; Melanoma; Skin tumors; Photo-dynamic therapy (PDT); ROS
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From green to red – To more dead? Autofluorescent proteins as photosensitizers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 98, Issue 1, 21 January 2010, Pages 95–98
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us