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2,3-Dihydroquinazolin-4(1H)-ones: Visible light mediated synthesis, solvatochromism and biological activity

Paper ID Volume ID Publish Year Pages File Format Full-Text
30062 44457 2015 9 PDF Available
Title
2,3-Dihydroquinazolin-4(1H)-ones: Visible light mediated synthesis, solvatochromism and biological activity
Abstract

•2,3-Dihydroquinazolin-4(1H)-ones synthesized under visible light.•Solvatochromism studies have been carried out.•In vitro anti-inflammatory activity by BSA has been carried out.•2,2-Di(4-t-octylphenyl)-1-picrylhydrazyl (DOPPH) radical scavenging has been done.

The photochemical synthesis of a series of 2,3-dihydroquinazolin-4(1H)-ones were evaluated under the irradiation of visible light (>390 nm). The effect of the visible light mediated synthesis was carried out in the presence/absence of solvent. The effect of solvent plays a key role in the synthesis was evidenced through the formation of product in short duration. The solvatochromic effects of the fluorescent compounds (3a–k) were studied with respect to the solvents of increasing polarity (DCM < methanol < DMF < DMSO). The determination of in vitro anti-inflammatory activity of the compounds (3a–k) by the inhibition of bovine serum albumin (BSA) denaturation and 2,2-di(4-t-octylphenyl)-1-picrylhydrazyl (DOPPH) radical scavenging consequence of the compounds (3a–k) were determined by spectroscopic technique. The compound 3j in DMSO exhibited extreme high quantum yield. The compound 3i was found to be superior both in the efficiency of the anti-inflammatory activity and radical scavenging ability.

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2,3-Dihydroquinazolin-4(1H)-ones: Visible light mediated synthesis, solvatochromism and biological activity
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 143, February 2015, Pages 139–147
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us