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Synthesis and crystal structure of new dicopper(II) complexes with N,N′-bis-(dipropylenetriamine)oxamide as bridging ligand: Effects of the counterions on DNA/protein-binding property and in vitro antitumor activity

Paper ID Volume ID Publish Year Pages File Format Full-Text
30063 44457 2015 15 PDF Available
Title
Synthesis and crystal structure of new dicopper(II) complexes with N,N′-bis-(dipropylenetriamine)oxamide as bridging ligand: Effects of the counterions on DNA/protein-binding property and in vitro antitumor activity
Abstract

•Two new dicopper(II) complexes were synthesized and structurally characterized.•The DNA/protein-binding properties were investigated.•The two complexes exhibited cytotoxicities following the order 2 > 1.•The influence of different counterions on the structure and property was studied.

Two new dicopper(II) complexes bridged by N,N′-bis(dipropylenetriamine)oxamide (H2oxdipn), namely, [Cu2(oxdipn)](pic)2(1) and [Cu2(oxdipn)(ClO4)2] (2), where pic represents picrate ion, have been synthesized and characterized by elemental analyses, molar conductance measurements, IR and electronic spectral studies, and X-ray single crystal diffraction. In both dicopper(II) complexes, the two copper(II) ions are bridged by trans-oxdipn ligand with the Cu⋯Cu separations of 5.2536(15) and 5.231(2) Å, respectively. The copper(II) ion in complex 1 has a square-planar coordination geometry, while that in 2, a square-pyramidal. Linked with classical hydrogen bonds, the molecules of complex 1 consist of a one-dimensional chain, while complex 2 molecules result in a two-dimensional structure. Numerous hydrogen bonds link complex 1 or 2 into a 2-D infinite network. In vitro cytotoxicity experiment shows that the two dicopper(II) complexes exhibit cytotoxic effects against the selected tumor cell lines. The reactivity towards herring sperm DNA (HS-DNA) and bovine serum albumin (BSA) reveals that the two dicopper(II) complexes can interact with the DNA in the mode of intercalation, and effectively quench the intrinsic fluorescence of BSA via a static mechanism. The influence of different counterions in this kind of dicopper(II) complexes on DNA/BSA-binding properties, and the in vitro cytotoxic activities was investigated.

Graphical abstractThe DNA/protein-binding and in vitro anticancer activities of two new synthesized dicopper(II) complexes were investigated.Figure optionsDownload full-size imageDownload as PowerPoint slide

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Synthesis and crystal structure of new dicopper(II) complexes with N,N′-bis-(dipropylenetriamine)oxamide as bridging ligand: Effects of the counterions on DNA/protein-binding property and in vitro antitumor activity
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 143, February 2015, Pages 148–162
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us