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Photodynamic inactivation of mold fungi spores by newly developed charged corroles

Paper ID Volume ID Publish Year Pages File Format Full-Text
30083 44459 2014 8 PDF Available
Title
Photodynamic inactivation of mold fungi spores by newly developed charged corroles
Abstract

•Novel cationic and anionic water soluble phosphorus corroles.•Photosensitizers with high singlet oxygen quantum yield and high photostability.•Efficient photodynamic growth inhibition of mold fungi.•Complete inactivation of mold fungi conidia by photodynamic effect.

The photodynamic effect, originally used in photodynamic therapy (PDT) for the treatment of different diseases, e.g. of cancer, has recently been introduced for the inactivation of bacteria. Mold fungi, which provoke health problems like allergies and diseases of the respiratory tract, are even more resistant and their biology is also very different. This study presents the development of four new photosensitizers, which, in combination with low doses of white light, inhibit the germination of mold fungi spores. Two of them even cause lethal damage to the conidia (spores) which are responsible for the spreading of mold fungi. The photoactivity of the newly synthesized corroles was obtained by their application on three different mold fungi: Aspergillus niger, Cladosporium cladosporoides, and Penicillium purpurgenum. To distinguish between inactivation of germination and permanent damage, the fungi were first incubated under illumination for examination of photosensitizer-induced growth inhibition and then left in darkness to test the survival of the conidia. None of the compounds displayed dark toxicity, but all of them attenuated or prevented germination when exposed to light, and the positively charged complexes induced a complete damage of the conidia.

Keywords
Photodynamic effect; Singlet oxygen generation; Phototoxicity; Mold fungi; Conidia; Cladosporium; Aspergillus; Penicillium; Charged corroles
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Photodynamic inactivation of mold fungi spores by newly developed charged corroles
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 133, 5 April 2014, Pages 39–46
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us