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Spectroscopical study of bacteriopurpurinimide–naphthalimide conjugates for fluorescent diagnostics and photodynamic therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
30094 44459 2014 5 PDF Available
Title
Spectroscopical study of bacteriopurpurinimide–naphthalimide conjugates for fluorescent diagnostics and photodynamic therapy
Abstract

•Two novel ABPI and NI dye conjugates with different linker groups were prepared.•The use of less rigid linker enables the higher emission intensity from the NI fragment.•The results were rationalized in terms of FRET interaction between the ABPI and NI units.

Two novel bis(chromophoric) dyads ABPI–NI1 and ABPI–NI2 containing 1,8-naphthalimide and bacteriopurpurinimide units linked by p-phenylene-methylene (ABPI–NI1) and pentamethylene (ABPI–NI2) spacers were prepared to test their ability to be used in the design of effective agents for both photodynamic therapy (PDT) and fluorescent tumor imaging. Photophysical studies revealed that the emission from the naphthalimide chromophore in both conjugates was partially quenched due to resonance energy transfer between the photoactive components. Compound ABPI–NI2 with more sterically flexible oligomethylene group demonstrated higher fluorescence intensity as compared with that for ABPI–NI1.

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Keywords
1,8-Naphthalimide; Bacteriopurpurinimide; Conjugate; Photodynamic therapy; Fluorescence imaging; Resonance energy transfer; PM6 semiempirical calculations
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Spectroscopical study of bacteriopurpurinimide–naphthalimide conjugates for fluorescent diagnostics and photodynamic therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 133, 5 April 2014, Pages 140–144
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
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