fulltext.study @t Gmail

Effect of 2-deoxy-d-glucose induced metabolic stress on testicular steroidogenesis and antioxidant status in golden hamster,Mesocricetus auratus: Role of photoperiod.

Paper ID Volume ID Publish Year Pages File Format Full-Text
30103 44460 2015 11 PDF Available
Title
Effect of 2-deoxy-d-glucose induced metabolic stress on testicular steroidogenesis and antioxidant status in golden hamster,Mesocricetus auratus: Role of photoperiod.
Abstract

•2-DG administration inhibits testicular steroidogenesis and antioxidant status in CP and LD hamsters.•SD buffered 2-DG induced suppression of steroidogenesis and antioxidant status via elevated melatonin level.•Unaltered testicular steroidogenesis following 2-DG treatment supports ‘floor effect’ under SD.•SD resisted 2-DG induced elevation in plasma corticosterone and protected testes from oxidative damages.

The driving force underlying the evolution of reproductive seasonality is the marked seasonal fluctuation in energy availability. It is well established that photoperiod regulates testicular steroidogenesis through modulation of circulatory and local melatonin levels and MT1R expression in golden hamster. However, photoperiodic variation in energy availability and its impact on testicular steroidogenesis and antioxidant status has never been investigated for any seasonal breeder. Therefore, the aim of the present study is to elucidate the role of photoperiod in modulation of metabolic stress induced variation in steroidogenesis and antioxidant status in testes. We experimentally reduced energy availability via administration of 2-deoxy-d-glucose (2-DG), a synthetic glucose analog, in critical- (CP), long- (LD) and short-day (SD) exposed golden hamsters, Mesocricetus auratus and examined testicular steroidogenesis and antioxidant status. Administration of 2-DG decreased testicular steroidogenesis and antioxidant enzyme activity in CP and LD experienced hamsters as compared to CP- and LD-control groups. Moreover, a decrease in the plasma- and local-melatonin level and MT1R expression in testes with a simultaneous increase in plasma corticosterone level was noted following 2-DG administration in CP and LD exposed hamsters. In contrast, no significant effect of 2-DG administration was observed on the parameters investigated under SD condition. Therefore, it can be suggested that the reduction in energy availability under CP and LD condition suppressed testicular steroidogenesis and increased oxidative damage in testis whereas SD induced melatonin might have buffered the 2-DG induced suppression of testicular steroidogenesis and maintained testicular antioxidant status.

Keywords
Photoperiod; 2-deoxy-d-glucose; Testes; Steroidogenesis; Antioxidant enzymes; Melatonin; Golden hamster
First Page Preview
Effect of 2-deoxy-d-glucose induced metabolic stress on testicular steroidogenesis and antioxidant status in golden hamster,Mesocricetus auratus: Role of photoperiod.
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 153, December 2015, Pages 40–50
Authors
, ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us