fulltext.study @t Gmail

Melatonin as a possible antidote to UV radiation induced cutaneous damages and immune-suppression: An overview

Paper ID Volume ID Publish Year Pages File Format Full-Text
30131 44460 2015 8 PDF Available
Title
Melatonin as a possible antidote to UV radiation induced cutaneous damages and immune-suppression: An overview
Abstract

•UV radiation induces severe oxidative damages to the body physiology.•The disturbance of the redox balance induces stress mediated apoptosis and inflammatory reactions.•Melatonin being an antioxidant helps alleviate the UV radiation mediated damages.•Apoptosis occurring due to UV radiation might be attenuated by melatonin administration.•Melatonin can be the future prognostic approach to alleviate UV radiation mediated damages leading to skin carcinogenesis.

The sun rays brings along the ultraviolet radiations (UVRs) which prove deleterious for living organisms. The UVR is a known mutagen and is the prime cause of skin carcinomas. UVR causes acute oxidative stress and this in turn deteriorates other physiological functions. Inflammatory conditions and elevation of pro-inflammatory molecules are also associated with UVR mediated cellular damages. The inflammatory conditions can secondarily trigger the generation of free radicals and this act cumulatively in further deterioration of tissue homeostasis. Photoimmunologists have also related UVR to the suppression of not only cutaneous but also systemic immunity by different mechanisms. Some researchers have proposed the use of various plant products as antioxidants against UVR induced oxidative imbalances but Melatonin is gaining rapid interest as a product that can be utilized to delineate the pathological effects of UVR since it is an established antioxidant. Besides the antioxidative nature, the capacity of melatonin to attenuate apoptosis and more importantly the efficacy of its metabolites to further aid in the detoxification of free radicals have made it a key player to be utilized against UVR mediated aggravated conditions. However, there is need for further extensive investigation to speculate melatonin as an antidote to UVR. Although too early to prescribe melatonin as a clinical remedy, the hormone can be integrated into dermal formulations or oral supplements to prevent the ever increasing incidences of skin cancers due to the prevalence of the UVR on the surface of the earth. The present review focuses and substantiates the work by different photo-biologists demonstrating the protective effects of melatonin and its metabolites against solar UVR — Melatonin as a possible antidote to UV radiation induced cutaneous damages and immune-suppression: an overview. J Photochem Photobiol B.

Keywords
UV radiation; Apoptosis; Free radicals; Melatonin; Antioxidant
First Page Preview
Melatonin as a possible antidote to UV radiation induced cutaneous damages and immune-suppression: An overview
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 153, December 2015, Pages 281–288
Authors
, ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us