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Chiral manganese (IV) complexes derived from Schiff base ligands: Synthesis, characterization, in vitro cytotoxicity and DNA/BSA interaction

Paper ID Volume ID Publish Year Pages File Format Full-Text
30155 44460 2015 10 PDF Available
Title
Chiral manganese (IV) complexes derived from Schiff base ligands: Synthesis, characterization, in vitro cytotoxicity and DNA/BSA interaction
Abstract

•Four chiral Schiff-base Mn (IV) complexes were synthesized and characterized.•The interaction of the Mn (IV) complexes with CT-DNA/BSA was also investigated.•In vitro cytotoxicity of the Mn (IV) complexes was tested by the MTT method.

Two new couples of chiral manganese (IV) complexes with Schiff-base ligands, Λ-[Mn(R-L1)2]·2(CH3OH) (Λ-1) and Δ-[Mn(S-L1)2]·2(CH3OH) (Δ-1), Λ-[Mn(R-L2)2]·(H2O)2 (Λ-2) and Δ-[Mn(S-L2)2]·(H2O)2 (Δ-2), {H2L1 = (R/S)-(±)-1-[(1-hydroxymethyl-propylimino)-methyl]-naphthalen-2-ol, H2L2 = (R/S)-(±)-1-[(1-Hydroxymethyl-2-phenyl-ethylimino)-methyl]-naphthalen-2-ol} have been synthesized, and fully characterized by elemental analyses, UV–Vis spectrum, circular dichroism spectrum, FT-IR spectrum, mass spectrum, and single crystal X-ray diffraction (SXRD). The interaction of the four chiral Mn (IV) complexes with CT-DNA and BSA were also investigated by various spectroscopic techniques (UV–visible, fluorescence spectroscopic). The results show that the Δ-complexes exhibit more efficient CT-DNA interaction with respect to the Λ-complexes. All the complexes could quench the intrinsic fluorescence of BSA by a static quenching process. In addition, the vitro cytotoxicity of these complexes toward four kinds of cancerous cell lines (A549, HeLa, HL-60, and Caco-2) was assayed by the MTT method, which exhibited to be selectively active against certain cell lines.

Graphical AbstractFour Schiff-base manganese (IV) complexes were synthesized and characterized, which trigger significant anti-proliferative effects in cancer cell lines. Spectroscopy determination reveals that the complexes from (S)-Schiff base ligands show stronger DNA/BSA interaction than complexes from (R)-Schiff base ligands.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Chiral Schiff-base; Manganese complexes; DNA binding; BSA interaction; Cytotoxicity
First Page Preview
Chiral manganese (IV) complexes derived from Schiff base ligands: Synthesis, characterization, in vitro cytotoxicity and DNA/BSA interaction
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 153, December 2015, Pages 473–482
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering