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CDBA-liposome as an effective sunscreen with longer UV protection and longer shelf life

Paper ID Volume ID Publish Year Pages File Format Full-Text
30186 44463 2013 9 PDF Available
Title
CDBA-liposome as an effective sunscreen with longer UV protection and longer shelf life
Abstract

•An azobenzene derivative-liposome as sunscreen with longer UV protection and longer shelf life.•Structure of CDBA-liposome is stable upon periodic UV and visible light irradiation.•The CDBA-liposome shows protective function for both UVA and UVB in vitro.•CDBA-liposome performs photo controlled release of encapsulated components.•CDBA-liposome provides a longer and good UV protection in vivo with nude mouse.

Harmful effects caused by the absorption of ultraviolet (UV) light can be reduced by using sunscreens. The long-wavelength UV (UVA) and short-wavelength UV (UVB) protective effects of an azobenzene compound, 4-cholesterocarbonyl-4′-(N,N′-diethylaminobutyloxy) azobenzene (CDBA) liposomal formulation, especially its repeated photo-isomerization were evaluated in the presence of substrates such as propylene glycol and glycerol. It was indicated that periodic UV and visible light irradiation did not affect the photo-isomerization and the structure of CDBA-liposome. The stability and photo-isomerization of CDBA-liposomes were not affected by coexistence of 5% propylene glycol and 5% glycerol. CDBA-liposomes could still perform photo-controlled release of encapsulated active component when mixed with propylene glycol. Moreover, the CDBA-liposome mixed with the cream substrate showed protective function for both UVA and UVB in vitro. The in vivo tests using nude mouse confirmed that the CDBA-liposome could provide a good UV protective efficacy with longer shelf life. Therefore, CDBA-liposomes have the potential using as a new type of commercial sunscreen.

Keywords
CDBA-liposome; Photo-isomerization; Sunscreen cosmetic; Ultraviolet irradiation; Longer shelf life
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CDBA-liposome as an effective sunscreen with longer UV protection and longer shelf life
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 129, 5 December 2013, Pages 78–86
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us