fulltext.study @t Gmail

The agr function and polymorphism: Impact on Staphylococcus aureus susceptibility to photoinactivation

Paper ID Volume ID Publish Year Pages File Format Full-Text
30189 44463 2013 8 PDF Available
Title
The agr function and polymorphism: Impact on Staphylococcus aureus susceptibility to photoinactivation
Abstract

•S. aureus response to PDI is strain dependent and multifactorial.•Functionality of the agr system affects S. aureus susceptibility to PDI.•Agr polymorphism influences S. aureus response to photodynamic treatment.

Staphylococcus aureus is an important human pathogen that causes healthcare-associated and community-acquired infections. Moreover, the growing prevalence of multiresistant strains requires the development of alternative methods to antibiotic therapy. One effective therapeutic option may be antimicrobial photodynamic inactivation (aPDI). Recently, S. aureus strain-dependent response to PDI was demonstrated, although the mechanism underlying this phenomenon remains unexplained. The aim of the current study was to investigate statistically relevant correlations between the functionality and polymorphisms of agr gene determined for 750 methicillin-susceptible and methicillin-resistant S. aureus strains and their responses to photodynamic inactivation using protoporphyrin IX. An AluI and RsaI digestion of the agr gene PCR product revealed existing correlations between the determined digestion profiles (designations used for the first time) and the PDI response. Moreover, the functionality of the agr system affected S. aureus susceptibility to PDI. Based on our results, we conclude that the agr gene may be a genetic factor affecting the strain dependent response to PDI.

Keywords
Accessory gene regulator; Gene polymorphism; Photoinactivation; Staphylococcus aureus
First Page Preview
The agr function and polymorphism: Impact on Staphylococcus aureus susceptibility to photoinactivation
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 129, 5 December 2013, Pages 100–107
Authors
, , , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us