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Ultra-weak Delayed Luminescence in cancer research: A review of the results by the ARETUSA equipment

Paper ID Volume ID Publish Year Pages File Format Full-Text
30206 44464 2014 9 PDF Available
Title
Ultra-weak Delayed Luminescence in cancer research: A review of the results by the ARETUSA equipment
Abstract

•The role of photoinduced ultraweak luminescence in cancer research is pointed out.•Normal and cancer cells discrimination and test of anticancer drugs are reported.•Advanced detection systems, employing small volumes of cell cultures, are described.•Data modelling by hyperbolic trends gives useful parameters in cell discrimination.•The role of MRC Complex I in photoinduced ultraweak luminescence is envisaged.

The study of the photoinduced ultraweak photon emission in the optical wavelength range, namely the Delayed Luminescence, from human cells and tissues has an increasingly growing interest in view of its possible application in optical biopsy. Due to the low level, dedicated experimental set-up are necessary to reveal such photoluminescence signal. The paper reviews the results obtained in the field of cancer research, by using the experimental equipment for fast ultraweak luminescence analysis ARETUSA developed at the National Southern Laboratories of the National Nuclear Physics Institute (LNS-INFN), in Catania, Italy. Delayed Luminescence signals from normal and cancer cells are compared and the relationship between Delayed Luminescence and apoptosis is investigated.

Keywords
Ultraweak luminescence; Photon detection; Modelling data; Cancer diagnosis; Apoptosis; Leukemia treatments
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 139, 5 October 2014, Pages 76–84
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us