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Interactions of zearalenone with native and chemically modified cyclodextrins and their potential utilization

Paper ID Volume ID Publish Year Pages File Format Full-Text
30217 44465 2015 6 PDF Available
Title
Interactions of zearalenone with native and chemically modified cyclodextrins and their potential utilization
Abstract

•Interactions of zearalenone (ZEA) with cyclodextrins (CDs) were investigated.•CDs form stable complexes with ZEA and strongly enhance its fluorescence.•CDs form more stable complexes with nonionic ZEA than with its deprotonated form.•Some of the CDs are able to inhibit cellular uptake of ZEA.

Zearalenone (ZEA) is a widespread xenoestrogenic mycotoxin produced by several Fusarium species. ZEA can cause reproductive disorders in farm animals and hyperoestrogenic syndromes in humans; therefore, development of more sensitive analytical methods (to quantify the mycotoxin) as well as strategies for prevention of its toxic impacts is highly important. In this study, the interactions of ZEA with native and chemically modified cyclodextrins (CDs) were investigated using fluorescence spectroscopy. Furthermore, in vitro experiments on liver cells were also performed to test the potential effect of CDs on toxin uptake. Our results demonstrate that ZEA forms stable complexes with CDs (log K values are approximately 3.7–4.7) resulting in the considerable elevation of its fluorescence signal. In addition, some of the CDs show ability to inhibit the cellular uptake of ZEA, suggesting their potential suitability to develop new CD-based preventive/detoxification strategies against ZEA in the future.

Keywords
Zearalenone; Cyclodextrin; Fluorescence spectroscopy; Fluorescence enhancement; Detoxification
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Interactions of zearalenone with native and chemically modified cyclodextrins and their potential utilization
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 151, October 2015, Pages 63–68
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us