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Mangiferin and naringenin affect the photostability and phototoxicity of sunscreens containing avobenzone

Paper ID Volume ID Publish Year Pages File Format Full-Text
30239 44465 2015 9 PDF Available
Title
Mangiferin and naringenin affect the photostability and phototoxicity of sunscreens containing avobenzone
Abstract

•The influence of two antioxidants on the photostability and phototoxicity of three UV-filters was assessed.•Naringenin and avobenzone degraded after UV exposure.•3T3 NRU phototoxicity test showed avobenzone presented a pronounced phototoxicity.•Combination CN (OMC, OCT, AVO, naringenin) presented phototoxic potential.•Mangiferin increased the photostability and reduced the phototoxic potential of naringenin and avobenzone combination.

Efficient UV-absorbing molecules are designed to protect against UV-light exposure. However, the development of photostable sunscreens is important to preserve the photoprotective efficacy and to prevent the formation of reactive oxygen species (ROS) and photodegradation products, which can promote phototoxic or photoallergic contact dermatitis. The aim of this study was to evaluate the effects of mangiferin and naringenin on the photostability and phototoxicity of sunscreens containing avobenzone. Cosmetic sunscreen formulations containing octocrylene (OCT), octyl methoxycinnamate (OMC) and avobenzone (AVO) were prepared and supplemented or not with mangiferin, naringenin, or with both compounds in combination. For photostability studies, samples of the formulations were spread onto glass plates, exposed to UVA radiation and then analyzed by high performance liquid chromatography (HPLC) to determine UV filters and the antioxidants recovery. The phototoxicity of the UV filters and antioxidants was evaluated using 3T3 fibroblast cultures that were subjected (or not) to irradiation according to OECD TG 432. The photostability studies demonstrated that AVO and naringenin showed the highest photodegradation when present in formulation FN (containing octocrylene, avobenzone, octyl methoxycinnamate and naringenin). The addition of mangiferin to this combination (FMN) resulted in an improved photostability of both substances compared to FN. The in vitro phototoxicity test showed that only avobenzone was considered phototoxic. The combination containing AVO/naringenin exhibited phototoxic potential; however, this was reduced by the addition of mangiferin (combination CMN). The results of this study are promising because it was demonstrated that mangiferin could increase the photostability and reduce the phototoxic potential of the combination of naringenin and AVO.

Keywords
+UV, presence of irradiation; −UV, absence of irradiation; 3T3 NRU PT, 3T3 Neutral Red Uptake Phototoxicity Test; AVO, avobenzone; C, combination containing octocrylene, avobenzone and octyl methoxycinnamate; CM, combination containing octocrylene, avoben
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 151, October 2015, Pages 239–247
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us