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Fluorescence properties of trans-ethyl-p-(dimethylamino) cinnamate in presence of bile acid host

Paper ID Volume ID Publish Year Pages File Format Full-Text
30252 44466 2009 8 PDF Available
Title
Fluorescence properties of trans-ethyl-p-(dimethylamino) cinnamate in presence of bile acid host
Abstract

The knowledge of the formation of bile acid micellar aggregates is of great importance because of the biological significance of these compounds and their pharmacological applications. The intramolecular charge transfer (ICT) fluorescence property of trans-ethyl-p-(dimethylamino) cinnamate is used to study the micelles formed by aggregation of three most important bile acids, viz. cholic acid, deoxycholic acid and chenodeoxycholic acid by steady state and picosecond time-resolved fluorescence spectroscopy. The ICT fluorescence band intensity was found to increase with concomitant blue shift with the addition of bile acids. The blue shift in ICT fluorescence maxima as well as decrease in nonradiative decay constants in presence of bile acids indicate the passage of the probe towards the micro domains formed from the aggregated bile acids. Binding constant of the probe with micelles as well as critical micelle concentration and average polarity parameter of the micellar environments were obtained from the variation of fluorescence intensity on increasing concentration of bile acids in the medium.

Keywords
Fluorescence; Intramolecular charge transfer; Bile acid; Critical micelle concentration; Binding constant; Non-radiative relaxation
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Fluorescence properties of trans-ethyl-p-(dimethylamino) cinnamate in presence of bile acid host
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 96, Issue 3, 4 September 2009, Pages 193–200
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
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100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us