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Evaluation of vascular effect of Photodynamic Therapy in chorioallantoic membrane using different photosensitizers

Paper ID Volume ID Publish Year Pages File Format Full-Text
30276 44468 2014 7 PDF Available
Title
Evaluation of vascular effect of Photodynamic Therapy in chorioallantoic membrane using different photosensitizers
Abstract

•The vascular effect of PDT is dependent on PS concentration.•Chlorins shows faster effect than porphyrins.•The intravenous injection is more efficient than topic administration.

Photodynamic Therapy (PDT) is a local treatment that requires a photosensitizing agent, light and molecular oxygen. With appropriate illumination, the photosensitizer is excited and produces singlet oxygen that is highly reactive and cytotoxic. Tumor vascular network is essential for the tumor growth and the understanding of vascular response mechanisms enables an improvement in the PDT protocol for cancer treatment. Compounds of porphyrin (Photogem®) and chlorin (Photodithazine®) were the photosensitizers tested. The incubation times varied from 20 to 80 min and the concentration ranged between 0.1 and 100 μg/cm2. Different light doses were used between 4.8 and 40 J/cm2 with irradiance varying between 80 and 100 mW/cm2. The light dose of 30 J/cm2 was used in the intravenous photosensitizer application. The membrane images were made from 0 to 300 min after treatment. The vascular response was evaluated by the average vessel area. Different responses was observed depending on the photosensitizer concentration and administration form. Intravenous application has been more efficient to produce vessel constriction and the most pronounced effect was observed for the chlorin.

Keywords
Photodynamic Therapy; Vascular effect; Chorioallantoic membrane; CAM; PDT
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Evaluation of vascular effect of Photodynamic Therapy in chorioallantoic membrane using different photosensitizers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 138, 5 September 2014, Pages 1–7
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us