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Quercetin deformable liposome: Preparation and efficacy against ultraviolet B induced skin damages in vitro and in vivo

Paper ID Volume ID Publish Year Pages File Format Full-Text
30319 44469 2013 10 PDF Available
Title
Quercetin deformable liposome: Preparation and efficacy against ultraviolet B induced skin damages in vitro and in vivo
Abstract

•Quercetin deformable liposomes were prepared using various surfactants.•Physical characteristics of deformable liposomes were investigated.•Deformable liposomes increased the protect effect in vitro against UVB-irradiation.•Deformable liposomes increased in vitro skin permeation and deposition of quercetin.•Edema and inflammation induced by UVB were alleviated by quercetin deformable liposomes in vivo.

Ultraviolet (UV) radiation has deleterious effects on cells through direct damage to DNA or through increasing generation of reactive oxygen species (ROS). The flavonol quercetin (Qu) provides cellular protection against UV radiation and the current investigation was carried out to develop a deformable liposome formulation of Qu to enhance its delivery into human skin and to improve its anti-UVB effect. The influence of surfactants (including Span 20, Tween 80 and sodium cholate) on the properties of Qu deformable liposomes was investigated. Liposomes composed of Qu, phosphatidylcholine (PC), cholesterol (Chol), and Tween 80 showed high entrapment efficiencies (80.41 ± 4.22%), small particle sizes (132 ± 14 nm), high elasticity (10.48 ± 0.71), and prolonged drug release. The cell viability in UVB-irradiated HaCaT cells increased to 89.89 ± 4.5% at 24 h and 78.8 ± 3.19% at 48 h following treatment with Qu defomable liposomes. The ROS and malondialdehyde (MDA) level were also reduced. The penetration rate was 3.8-fold greater than that of the Qu suspension. Moreover, the edema and inflammation was alleviated by Qu deformable liposomes. These results showed the potential of deformable liposomes to enhance the anti-UVB effects of Qu both in vitro and in vivo.

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Keywords
Quercetin; Deformable liposome; Anti-UVB; ROS; HaCaT cells
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Quercetin deformable liposome: Preparation and efficacy against ultraviolet B induced skin damages in vitro and in vivo
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 127, 5 October 2013, Pages 8–17
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us