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Effect of polypeptide from Chlamys farreri on UVB-induced ROS/NF-κB/COX-2 activation and apoptosis in HaCaT cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
30348 44471 2009 8 PDF Available
Title
Effect of polypeptide from Chlamys farreri on UVB-induced ROS/NF-κB/COX-2 activation and apoptosis in HaCaT cells
Abstract

Polypeptide from Chlamys farreri (PCF) is a novel marine polypeptide compound isolated from gonochoric Chinese scallop Chlamys farreri, this study we further investigate the mechanisms of PCF exerting its anti-apoptotic effect. The results indicated that PCF, ROS scavenger NAC and NF-κB inhibitor MG132 effectively inhibited UVB-induced HaCaT cells apoptosis. PCF (2.84 mM) showed potential ROS scavenging activities in a kinetic process. PCF (1.42–5.69 mM) dose-dependently increased the expressions of Cu, Zn-SOD, CAT and GPx meanwhile decreased the expressions of p-NF-κB/p65 and COX-2 in UVB-induced HaCaT cells. Additionally, pretreatment with NAC significantly declined the generation of ROS and the expression of p-NF-κB/p65. We concluded that ROS, NF-κB and COX-2 are involved in UVB-induced HaCaT cells apoptosis, PCF exerts its protective effects via scavenging ROS, increasing the expression of antioxidative enzymes and inhibition the activation of NF-κB and COX-2.

Keywords
Polypeptide from Chlamys farreri (PCF); Reactive oxygen species (ROS); NF-κB; COX-2; Apoptosis
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Effect of polypeptide from Chlamys farreri on UVB-induced ROS/NF-κB/COX-2 activation and apoptosis in HaCaT cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 96, Issue 2, 3 August 2009, Pages 109–116
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us