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Theoretical investigation of the photosensitization mechanisms of urocanic acid

Paper ID Volume ID Publish Year Pages File Format Full-Text
30366 44474 2008 3 PDF Available
Title
Theoretical investigation of the photosensitization mechanisms of urocanic acid
Abstract

The photosensitization mechanisms of urocanic acid (UA), the main skin chromophores of ultraviolet (UV) light, are investigated by means of theoretical calculations. The results indicate that the direct photooxidative damage to DNA bases by triplet state UA through electron transfer reaction is not favorable on thermodynamic grounds. However, UA can photogenerate various reactive oxygen species (ROS, e.g., 1O2, O2-) theoretically and the ROS-generating mechanisms are illustrated as follows. Firstly, the 1O2-generating pathway involves direct energy transfer between triplet state UA and 3O2. Secondly, UA gives birth to O2- through two pathways: (i) direct electron transfer between triplet state UA and 3O2; (ii) electron transfer between anion radical of UA (generated through autoionization reactions) and 3O2.

Keywords
Urocanic acid; Photosensitization mechanisms; Reactive oxygen species; Density functional theory
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 91, Issues 2–3, 29 May 2008, Pages 96–98
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Price was $35.95
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