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Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system

Paper ID Volume ID Publish Year Pages File Format Full-Text
30381 44475 2014 10 PDF Available
Title
Combination of chemotherapy and photodynamic therapy using graphene oxide as drug delivery system
Abstract

•Combination therapy of chemotherapy and photodynamic therapy was evaluated.•Hypocrellin A and 7-ethyl-10-hydroxycamptothecin were co-loaded on graphene oxide.•The complex was formed through noncovalent π–π stacking and hydrogen bond.•Combination therapy exhibited a synergistic anticancer effect to cancer cell.

Previous research indicated that graphene oxide (GO) can be used to deliver photosensitive anticancer drug, Hypocrellin A (HA), in photodynamic therapy (PDT). However, the anticancer activity of HA was obviously decreased after been loaded on GO. To solve this problem, a chemotherapy drug, 7-ethyl-10-hydroxycamptothecin (SN-38), was co-loaded on the HA loaded GO (HA/SN-38/GO) as a multimodal carrier for the synergistic combination of PDT and chemotherapy for cancer. In vitro results showed that the combination therapy exhibited a synergistic antiproliferative effect compared with PDT and chemotherapy alone. Therefore, HA/SN-38/GO delivery system has the potential to offer dual therapies for the synergistic combination of PDT and chemotherapy for the treatment of cancer.

Graphical abstractGraphene oxide was exploited as a multimodal carrier of photosensitizers and chemotherapeutics for the synergistic combination therapy to cancer.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Hypocrellin A; 7-Ethyl-10-hydroxycamptothecin; Graphene oxide; Combination therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 135, 5 June 2014, Pages 7–16
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us