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Study on synthesis, crystal structure, antioxidant and DNA-binding of mono-, di- and poly-nuclear lanthanides complexes with bis(N-salicylidene)-3-oxapentane-1,5-diamine

Paper ID Volume ID Publish Year Pages File Format Full-Text
30384 44475 2014 11 PDF Available
Title
Study on synthesis, crystal structure, antioxidant and DNA-binding of mono-, di- and poly-nuclear lanthanides complexes with bis(N-salicylidene)-3-oxapentane-1,5-diamine
Abstract

•Three novel lanthanide(III) complexes have been synthesized and characterized.•The ligand and its Ln(III) complexes bind to DNA in a groove binding mode.•The Ln(III) complexes have the preferable ability to scavenge hydroxyl radical and superoxide radical.

A Schiff base ligand bis(N-salicylidene)-3-oxapentane-1,5-diamine H2L have been prepared. Reaction of the shape-specific designed ligand with Ln(NO3)3⋅6H2O afforded three novel complexes, namely, Sm(L)(NO3)(DMF)(H2O) 1, [Eu(H2L)2(NO3)3]n2 and Tb2(L)2(NO3)23. The ligand and complexes were characterized by elemental analysis, UV–Vis, IR, NMR spectroscopy and X-ray crystallography. It is noteworthy that the complexes demonstrate three different types of the structure which changed according to the charge density and acidity of the lanthanide. Complex 1 is a discrete mononuclear species that Sm(III) ion is nine-coordinated in the structure and forming a distorted tricapped trigonal prism geometry. Complex 2 is possessed a 1-D ribbon framework constructed from an extended array of ten-coordinated Eu3+ centers and the Schiff base ligands. Complex 3 is revealed as a centrosymmetric binuclear neutral entity, in which Tb(III) ion is eight-coordinated with the coordination surround of distorted square antiprism geometry. In order to explore the relationship between the structure and biological properties, the DNA-binding properties have been investigated by electronic absorption, fluorescence, and viscosity measurements. The results suggest that the ligand and complexes bind to DNA via groove modes. The intrinsic binding constants Kb of the complexes 1–3 are (1.19 ± 0.112) × 105, (4.22 ± 0.086) × 104 and (3.89 ± 0.104) × 104 M−1 respectively. Moreover, the antioxidant activity experiments show that these compounds also exhibit good antioxidant activities against OH and O2− in vitro studies.

Graphical abstractThree novel structure Ln(III) complexes (Ln = Sm, Eu and Tb) have been synthesized and characterized systematically. The ligand and Ln(III) complexes bind to DNA in a groove mode. Three Ln(III) complexes have a strong potential to be applied as scavengers to eliminate the radicals.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Bis(N-salicylidene)-3-oxapentane-1,5-diamine; Lanthanide(III) complex; Crystal structure; DNA-binding property; Antioxidant activity
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Study on synthesis, crystal structure, antioxidant and DNA-binding of mono-, di- and poly-nuclear lanthanides complexes with bis(N-salicylidene)-3-oxapentane-1,5-diamine
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 135, 5 June 2014, Pages 33–43
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us