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Study of UVA irradiation on hemoglobin in the presence of NADH

Paper ID Volume ID Publish Year Pages File Format Full-Text
30410 44477 2008 4 PDF Available
Title
Study of UVA irradiation on hemoglobin in the presence of NADH
Abstract

Reduction of ferric methemoglobin (metHb) to its ferrous form is observed by short-time ultraviolet A (UVA) irradiation of metHb together with nicotinamide adenine dinucleotide (NADH). And, severely structural destruction of metHb occurs when long-time UVA irradiation is exerted. However, neither reduction nor destruction can be observed in the absence of NADH under otherwise the same experimental conditions. Accordingly, the O2-binding ability of the protein increases by short-time UVA irradiation of metHb together with NADH, which corresponds with the reduction of metHb, while it decreases by long-time UVA irradiation, which corresponds with the structural destruction. Besides, it is found that the reduction reaction and the conformational destruction proceed more rapidly with higher concentrations of NADH.

Keywords
Hemoglobin; NADH; UVA irradiation; Bioelectrochemistry
First Page Preview
Study of UVA irradiation on hemoglobin in the presence of NADH
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 90, Issue 1, 30 January 2008, Pages 53–56
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering