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Isolation and characterization of bioactive compounds from the bark of Litsea costalis

Paper ID Volume ID Publish Year Pages File Format Full-Text
30471 44480 2013 7 PDF Available
Title
Isolation and characterization of bioactive compounds from the bark of Litsea costalis
Abstract

•Four bioactive compounds were isolated from Litsea costalis.•Their structures and stereochemistry were determined using 1D and 2D NMR data.•IR and NMR data in combination with DFT confirm the structures of the compounds.•Compounds showed anticancer activity against cancer cells and antioxidant (DPPH).

The bark of Litsea costalis affords two new compounds named 4,4′-diallyl-5,5′-dimethoxy-[1,1′-biphennyl]-2,2′-diol, biseugenol A (1) and 2,2′-oxybis (4-allyl-1-methoxybenzene), biseugenol B (2) along with two known compounds (3–4), namely 5-methoxy-2-Hydroxy Benzaldehyde (3), and (E)-4-styrylphenol (4). The structures of 1 and 2 were determined using 1D and 2D NMR data. Also, the IR and NMR data were combined with quantum chemical calculations in the DFT approach using the hybrid B3LYP exchange–correlation function to confirm the structures of the compounds. Compounds showed fairly potent anticancer activity against cell lines and antioxidant (DPPH).

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Keywords
Litsea costalis; Extraction; NMR; DFT calculations; Cytotoxicity
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Isolation and characterization of bioactive compounds from the bark of Litsea costalis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 128, 5 November 2013, Pages 85–91
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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Don't Miss Today's Special Offer
Price was $35.95
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100% Money Back Guarantee
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