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The oxidative damages caused by ultraviolet radiation type C (UVC) to a tropical rodent Funambulus pennanti: Role of melatonin

Paper ID Volume ID Publish Year Pages File Format Full-Text
30527 44485 2013 7 PDF Available
Title
The oxidative damages caused by ultraviolet radiation type C (UVC) to a tropical rodent Funambulus pennanti: Role of melatonin
Abstract

•The UVC radiation being an oxidant caused oxidative load in the animal studied.•There was an increase in lipid peroxidation and decrease in antioxidant enzyme activities.•Melatonin being an antioxidant proved to be helpful in ameliorating the damages caused by UVC.•Apoptosis occurring due to UVC was lessened by melatonin administration.•Melatonin proved to be radio-protective against damages caused by UVC radiation both in vivo and in vitro.

Data suggests that UV radiation causes oxidative damage of the cells due to the release of inflammatory cytokines which in turn generates reactive oxygen species (ROS) that damages lipids, proteins and DNA. On the other hand, melatonin a potent antioxidant from the pineal gland under most of the conditions acts as a free radical scavenger. Our data suggests that melatonin pre-treatment (s.c. injections) significantly protected the diurnal squirrels from oxidative damages caused by UVC irradiation of 1528 mJ cm−2 that induced suppression of delayed type hypersensitivity (DTH) responses. It also protected the rodents from UVC radiation induced increase in thiobarbituric acid reactive substances (TBARS) levels in spleen accompanied with a significant decrease in Superoxide Dismutase (SOD) activity indicating the occurrence of superoxide anion mediated damages following UVC exposure. Melatonin administration reduced the radiation induced oxidative stress in the spleen tissue as analyzed by reduced lipid damages and higher SOD activity. Under in vivo (100 μg/100 g body wt.) and in vitro (250 pg/106 cells) conditions, melatonin pre-treatment prevented spleen tissues and splenocytes from radiation induced cell death.In conclusion we may suggest that melatonin could be one of the potent antioxidant and radio protector that may reduce UV radiation induced toxicity to the cells and hence may be clinically important.

Keywords
Melatonin; Apoptosis; TBARS; Immunity; UVC radiation
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The oxidative damages caused by ultraviolet radiation type C (UVC) to a tropical rodent Funambulus pennanti: Role of melatonin
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 125, 5 August 2013, Pages 19–25
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us