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Synthesis, structural characterization, DNA binding studies and antitumor properties of tin(II)-oxydiacetate complexes containing α-diimine as auxiliary ligand

Paper ID Volume ID Publish Year Pages File Format Full-Text
30546 44485 2013 8 PDF Available
Title
Synthesis, structural characterization, DNA binding studies and antitumor properties of tin(II)-oxydiacetate complexes containing α-diimine as auxiliary ligand
Abstract

•The present work describes synthesis and characterization of ternary complexes.•Complexes adopt distorted pbp geometry.•Extensive H-bonding and π–π interactions are present in complexes.•The complexes were screened against tumor cell lines.•DNA binding and cleavage experiments were also performed.

Metal directed supra molecular assemblies with interesting topologies have been widely used as models for metallo-enzymes and in development of metallo-pharmaceuticals. Two novel tin(II)-oxydiacetate complexes with α-diimine (1,10-phenanthroline or 2,2′-bipyridine) as auxiliary ligand were synthesized and characterized by elemental analysis, FT-IR, 1H-, 13C- and 119Sn-NMR and single crystal X-ray crystallography. The spectral investigations and X-ray data show that {Sn} is hepta coordinated with pentagonal bipyramidal (pbp) geometry of the complexes. The in vitro binding and cleavage studies using CT DNA by UV–visible, fluorescence and agarose gel electrophoresis techniques revealed that both complexes bind DNA via intercalation. The observed magnitudes of Kb for complexes (1) and (2) are 2.517 × 104 and 5.35 × 103, respectively, which suggest that (1) has strong binding affinity for CT DNA as compared to (2). The complexes were tested for antitumor properties and found highly active at 10−4 M concentration against P388, HL-60 and A-549 cell lines.

Graphical abstractTernary complexes containing oxydiacetic acid as primary and α-diimine as auxiliary ligands have been synthesized and characterized. Their DNA binding and antitumor properties have also been examined.Figure optionsDownload full-size imageDownload as PowerPoint slide

Keywords
Tin(II)-oxydiacetate complex; DNA binding; Crystal structure; Antitumor properties
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Synthesis, structural characterization, DNA binding studies and antitumor properties of tin(II)-oxydiacetate complexes containing α-diimine as auxiliary ligand
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 125, 5 August 2013, Pages 171–178
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us