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Isoquino[4,5-bc]acridines: Design, synthesis and evaluation of DNA binding, anti-tumor and DNA photo-damaging ability

Paper ID Volume ID Publish Year Pages File Format Full-Text
30616 44493 2006 6 PDF Available
Title
Isoquino[4,5-bc]acridines: Design, synthesis and evaluation of DNA binding, anti-tumor and DNA photo-damaging ability
Abstract

Several novel isoquino[4,5-bc]acridine derivatives have been designed and synthesized. Their DNA-binding, anti-tumor and DNA-photo-damaging properties were investigated. A4 exhibited the highest anti-tumor activities against both A 549 (human lung cancer cell) and P388 (murine leukemia cells). All these compounds were found to be more cytotoxic against P388 than against A549. Under 365-nm light irradiation, A3 damaged plasmid DNA pBR322 at <2 μM and cleaved DNA from form I to 100% form II by 50 μM. The mechanism studies revealed that A3 damaged DNA by electron transfer mechanism and singlet oxygen species.

Keywords
Acridine; DNA binding; DNA photo-cleavage; Anti-tumor activity
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Isoquino[4,5-bc]acridines: Design, synthesis and evaluation of DNA binding, anti-tumor and DNA photo-damaging ability
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 84, Issue 3, 1 September 2006, Pages 221–226
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us