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Folic acid-conjugated graphene oxide for cancer targeted chemo-photothermal therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
30641 44494 2013 7 PDF Available
Title
Folic acid-conjugated graphene oxide for cancer targeted chemo-photothermal therapy
Abstract

Nanographene oxide (NGO), a new type of nanomaterial for anticancer drugs delivery and near-infrared (NIR)-mediated photothermal ablation of tumors, has been used in the combination of photothermal therapy and chemotherapy. Herein, targeted chemo-photothermal therapy based on polyvinylpyrrolidone (PVP) functionalized NGO was achieved. Folic acid (FA), a common target molecule to cancer cells, was conjugated to NGO via covalent amide bond. The obtained FA–NGO–PVP was proved to be an ideal pH-responsive nanocarrier for delivery of an anticancer drug doxorubicin (DOX) with the loading ratio more than 100%. In vitro experiments were then performed with the combination of chemotherapy and NIR photothermal therapy. The results demonstrated that the targeted chemo-photothermal therapy could specifically deliver drug and heat to tumor sites and showed excellent efficacy of anticancer therapy. Thus, FA–NGO–PVP could be used as a novel nanomaterial for selective chemo-photothermal therapy.

► We investigated functionalized NGO for cancer targeted chemo-photothermal therapy. ► We developed FA–NGO–PVP loading with doxorubicine (DOX). ► FA–NGO–PVP was proved to be an ideal pH-responsive nanocarrier. ► We investigated the cell death induced by FA–NGO–PVP/DOX with 808 nm laser in vitro. ► FA–NGO–PVP/DOX under laser irradiation shown an excellent anticancer efficacy.

Keywords
Graphene oxide; Cancer; Targeting; Chemotherapy; Photothermal therapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 120, 5 March 2013, Pages 156–162
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us