fulltext.study @t Gmail

Saponins from Tribulus terrestris L. protect human keratinocytes from UVB-induced damage

Paper ID Volume ID Publish Year Pages File Format Full-Text
30672 44495 2012 9 PDF Available
Title
Saponins from Tribulus terrestris L. protect human keratinocytes from UVB-induced damage
Abstract

Chronic exposure to solar UVB radiation damages skin, increasing the risk to develop cancer. Hence the identification of compounds with a photoprotective efficacy is essential. This study examined the role of saponins derived from Tribulus terrestris L. (TT) on the modulation of apoptosis in normal human keratinocytes (NHEK) exposed to physiological doses of UVB and to evaluate their antitumoral properties. In NHEK, TT saponins attenuate UVB-induced programmed cell death through inhibition of intrinsic apoptotic pathway. In squamous cell carcinomas (SCC) TT saponins do not make the malignant keratinocytes more resistant to UVB and determine an enhanced apoptotic response. The photoprotective effect of TT saponins is tightly correlated to the enhancement of NER genes expression and the block of UVB-mediated NF-κB activation. Collectively, our study shows experimental evidence that TT has a preventive efficacy against UVB-induced carcinogenesis and the molecular knowledge on the mechanisms through which TT saponins regulate cell death suggests great potential for TT to be developed into a new medicine for cancer patients.

► The photoprotective role of Tribulus terrestris L. was studied upon UVB irradiation. ► In squamous cell carcinomas Tribulus determine an enhanced apoptotic response. ► The photoprotective effect is correlated to the enhancement of NER genes expression. ► The antitumoral effect occurs through the block of UVB-mediated NF-κB activation.

Keywords
Tribulus terrestris; Saponins; Keratinocytes; Apoptosis; Cancer; NF-κB
First Page Preview
Saponins from Tribulus terrestris L. protect human keratinocytes from UVB-induced damage
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 117, 5 December 2012, Pages 193–201
Authors
, , , , , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us