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Synthesis, crystal structure, DNA binding and in vitro biological studies of Ni(II), Cu(II) and Zn(II) complexes of N-phthaloylglycine

Paper ID Volume ID Publish Year Pages File Format Full-Text
30677 44495 2012 12 PDF Available
Title
Synthesis, crystal structure, DNA binding and in vitro biological studies of Ni(II), Cu(II) and Zn(II) complexes of N-phthaloylglycine
Abstract

Ni(II), Cu(II) and Zn(II) metal complexes of N-phthaloylglycine were synthesized, characterized, reported for single crystal X-ray diffraction analysis for Ni(II) complex, and investigated for their binding with DNA under physiological conditions, using spectroscopic (UV–visible and fluorescence) and hydrodynamic techniques. Experimental results from both spectroscopic methods were comparable and further supported by viscosity measurements. Binding constant “Kb” obtained from both spectroscopic methods revealed significant binding of compounds with DNA via intercalation. Among all compounds comparatively good DNA binding was found for Zn(II) complex. Free energies of compounds–DNA interactions indicated spontaneity of their binding. Dynamic and bimolecular enhancement values disclose static process involved in compounds–DNA complex formation. All compounds exhibited broad range antibacterial, while Zn(II) complex exhibited best antitumor activity.

Graphical abstractNi(II), Cu(II), Zn(II) complexes of N-phthaloylglycine were investigated for their binding with DNA and bioactivities. Among all Zn(II) complex showed comparatively good DNA binding via intercalation and better antitumor potential.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Synthesis characterisation of metal complexes of N-phthaloylglycine with Ni, Cu, Zn. ► Structural determination of Ni complex by X-ray crystallography. ► N-phthaloylglycine and its metal complexes interact with DNA via intercalation. ► Among all compounds comparatively good DNA binding was investigated for Zn complex. ► Zn complex showed better antibacterial and antitumor potential.

Keywords
Metal carboxylates; UV–visible spectroscopy; Fluorescence spectroscopy; DNA binding; Binding site size; Biological applications
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Synthesis, crystal structure, DNA binding and in vitro biological studies of Ni(II), Cu(II) and Zn(II) complexes of N-phthaloylglycine
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 117, 5 December 2012, Pages 228–239
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us