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Effects of intranasal phototherapy on nasal mucosa in patients with allergic rhinitis

Paper ID Volume ID Publish Year Pages File Format Full-Text
30697 44496 2007 7 PDF Available
Title
Effects of intranasal phototherapy on nasal mucosa in patients with allergic rhinitis
Abstract

RationaleRhinophototherapy has been shown to be effective in the treatment of allergic rhinitis. Considering that phototherapy with ultraviolet light (UV) induces DNA damage, it is of outstanding importance to evaluate the damage and repair process in human nasal mucosa.MethodsWe have investigated eight patients undergoing intranasal phototherapy using a modified Comet assay technique and by staining nasal cytology samples for cyclobutane pyrimidine dimers (CPDs), which are UV specific photoproducts.ResultsImmediately after last treatment Comet assay of nasal cytology samples showed a significant increase in DNA damage compared to baseline. Ten days after the last irradiation a significant decrease in DNA damage was observed compared to data obtained immediately after finishing the treatment protocol. Difference between baseline and 10 days after last treatment was not statistically significant. Two months after ending therapy, DNA damage detected by Comet assay in patients treated with intranasal phototherapy was similar with that of healthy individuals. None of the samples collected before starting intranasal phototherapy stained positive for CPDs. In all samples collected immediately after last treatment strong positive staining for CPDs was detected. The number of positive cells significantly decreased 10 days after last treatment, but residual positive staining was present in all the examined samples. This finding is consistent with data reported in skin samples after UV irradiation. Cytology samples examined two months after ending therapy contained no CPD positive cells.ConclusionOur results suggest that UV damage induced by intranasal phototherapy is efficiently repaired in nasal mucosa.

Keywords
Phototherapy; DNA damage; Nasal mucosa
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Effects of intranasal phototherapy on nasal mucosa in patients with allergic rhinitis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 89, Issues 2–3, 14 December 2007, Pages 163–169
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
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