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Monte Carlo simulation of near infrared autofluorescence measurements of in vivo skin

Paper ID Volume ID Publish Year Pages File Format Full-Text
30704 44497 2011 7 PDF Available
Title
Monte Carlo simulation of near infrared autofluorescence measurements of in vivo skin
Abstract

The autofluorescence properties of normal human skin in the near-infrared (NIR) spectral range were studied using Monte Carlo simulation. The light-tissue interactions including scattering, absorption and anisotropy propagation of the regenerated autofluorescence photons in the skin tissue were taken into account in the theoretical modeling. Skin was represented as a turbid seven-layered medium. To facilitate the simulation, ex vivo NIR autofluorescence spectra and images from different skin layers were measured from frozen skin vertical sections to define the intrinsic fluorescence properties. Monte Carlo simulation was then used to study how the intrinsic fluorescence spectra were distorted by the tissue reabsorption and scattering during in vivo measurements. We found that the reconstructed model skin spectra were in good agreement with the measured in vivo skin spectra from the same anatomical site as the ex vivo tissue sections, demonstrating the usefulness of this modeling. We also found that difference exists over the melanin fluorescent wavelength range (880–910 nm) between the simulated spectrum and the measured in vivo skin spectrum from a different anatomical site. This difference suggests that melanin contents may affect in vivo skin autofluorescence properties, which deserves further investigation.

► We modeled the near infrared autofluorescence properties of normal skin by Monte Carlo simulation. ► The modeling demonstrated how the intrinsic fluorescence spectra are distorted by the tissue reabsorption and scattering. ► The reconstructed model skin spectra were in good agreement with the measured in vivo skin spectra. ► The effect of melanin contents on in vivo skin autofluorescence properties deserves further investigation.

Keywords
Near infrared tissue fluorescence; Monte Carlo simulation; Skin optical model; Skin autofluorescence
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Monte Carlo simulation of near infrared autofluorescence measurements of in vivo skin
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 105, Issue 3, 2 December 2011, Pages 183–189
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us