A V-shaped ligand 1,3-bis(1-methylbenzimidazol-2-yl)-2-oxapropane and its Cu(II) complex: Synthesis, crystal structure, antioxidation and DNA-binding properties
A six-coordinate copper(II) complex with the ligand 1,3-bis(1-methylbenzimidazol-2-yl)-2-oxopropane (Meobb), with composition [Cu(Meobb)2](NO3)2·2CH3OH, has been synthesized and characterized by elemental analysis, electrical conductivities, IR, UV–Vis spectral measurements. A study of the electro-chemistry of the copper(II) complex was carried out by using cyclic voltammetry. The molecular structures of the ligand Meobb and the Cu(II) complex were determined by X-ray crystal diffraction. The DNA-binding modes of the ligand and the complex were investigated by electronic absorption titration, ethidium bromide–DNA displacement experiments and viscosity measurements. The experimental evidence indicated the compounds interact with calf thymus DNA through intercalation. Additionally, the Cu(II) complex exhibited potential antioxidant properties in in vitro studies.
Graphical abstractA new symmetrical bis-benzimidazole Cu(II) complex [Cu(Meobb)2](NO3)2·CH3OH was synthesized and characterized. The DNA binding properties and antioxidation were also investigated.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► A new Cu(II) complex has been synthesized and characterized systematically. ► The interaction of compounds with calf thymus DNA (CT-DNA) have been investigated. ► The antioxidation properties of Cu(II) complex were investigated.
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 105, Issue 3, 2 December 2011, Pages 190–197