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Effect of UV irradiation on the physico-chemical properties of iron crosslinked collagen

Paper ID Volume ID Publish Year Pages File Format Full-Text
30707 44497 2011 4 PDF Available
Title
Effect of UV irradiation on the physico-chemical properties of iron crosslinked collagen
Abstract

Collagen is the main component of connective tissue and finds immense applications as a biomaterial. In this study, effect of UV irradiation on collagen crosslinked with iron has been carried out. The physical and optical properties of crosslinked collagen affected by UV irradiation were analyzed using electrospectral and fluorescence studies. The electronic spectral studies showed that the photoproducts formed on UV radiation decrease in the presence of iron. Circular dichroic studies revealed that the conformational changes brought about in the protein due to UV irradiation have been reduced owing to the crosslinking with iron. However, prolonged irradiation does bring about conformational changes to the protein.

Graphical abstractThe effect of UV radiation on iron crosslinked collagen has been investigated. The response of native and iron crosslinked collagen to UV irradiation has been found to differ significantly. Iron crosslinking alleviates the negative effects of UV radiation.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Effect of UV radiation on iron crosslinked collagen studied. ► The physical and optical properties were analyzed using electrospectral, fluorescence and conformational studies. ► Iron crosslinking reduces the effect of UV irradiation.

Keywords
Collagen; UV radiation; Circular dichroism (CD); Fluorescence; Absorption; Iron
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Effect of UV irradiation on the physico-chemical properties of iron crosslinked collagen
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 105, Issue 3, 2 December 2011, Pages 203–206
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us