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Syntheses and structures of new trimetallic complexes bridged by N-(5-chloro-2-hydroxyphenyl)-N′-[3-(dimethylamino)propyl]oxamide: Cytotoxic activities, and reactivities towards DNA and protein

Paper ID Volume ID Publish Year Pages File Format Full-Text
30716 44498 2013 11 PDF Available
Title
Syntheses and structures of new trimetallic complexes bridged by N-(5-chloro-2-hydroxyphenyl)-N′-[3-(dimethylamino)propyl]oxamide: Cytotoxic activities, and reactivities towards DNA and protein
Abstract

Two new μ-oxamido-bridged trinuclear complexes, namely [Cu3L2(H2O)2]{[Cu3L2]·2H2O}2 (1) and [Ni3L2(H2O)(DMF)](H2O)(DMF) (2), where L3− is deprotonated N-(5-chloro-2-hydroxyphenyl)-N′-[3-(dimethylamino)propyl]oxamide, have been synthesized and characterized by X-ray single-crystal diffraction. The structure of complex 1, which consists of three tricopper(II) neutral molecules, lies on an inversion centre at Cu5 atom and thus has a trans conformation. The structure of complex 2 composes of a trinickel(II) neutral molecule. In vitro cytotoxic activities, and the reactivities of the two complexes towards DNA and protein are investigated. Cytotoxicities experiments reveal that the two trinuclear complexes both exhibits cytotoxic effects against human hepatocellular carcinoma cell SMMC-7721 and human lung adenocarcinoma cell A549. The interactions of the two complexes with herring sperm DNA (HS-DNA) are investigated by using UV absorption and fluorescence spectra and viscometry. The results suggested that both of the two trinuclear complexes could interact with HS-DNA through the intercalation mode and follow the binding affinity order of 1 > 2. The reactivity towards protein BSA revealed that the quenching of BSA fluorescence by the two complexes are static quenching, and complex 1 exhibits a higher BSA-binding ability than that of complex 2.

Graphical abstractTrinuclear complexes constructed from asymmetrical N,N′-bis(substituted)oxamide have been synthesized and characterized by X-ray single-crystal diffraction. The cytotoxicities and reactivities towards DNA and protein of the complexes have been investigated.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Two new μ-oxamido-bridged trinuclear complexes were synthesized. ► The two complexes were characterized by X-ray single-crystal diffraction. ► The two complexes exhibit cytotoxicities against SMMC-7721 and A549 cell lines. ► The DNA-binding abilities are consistent with cytotoxicities in the order 1 > 2. ► Complex 1 also exhibits higher BSA binding ability than that of complex 2.

Keywords
Crystal structure; Trinuclear complex; Cytotoxicity; DNA interaction; Protein binding
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Syntheses and structures of new trimetallic complexes bridged by N-(5-chloro-2-hydroxyphenyl)-N′-[3-(dimethylamino)propyl]oxamide: Cytotoxic activities, and reactivities towards DNA and protein
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 118, 5 January 2013, Pages 22–32
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us