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Electrically-responsive anti-adherent hydrogels for photodynamic antimicrobial chemotherapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
30742 44500 2012 12 PDF Available
Title
Electrically-responsive anti-adherent hydrogels for photodynamic antimicrobial chemotherapy
Abstract

The loading of the photosensitisers meso-Tetra (N-methyl-4-pyridyl) porphine tetra tosylate (TMP), methylene blue (MB) and TMP with sodium dodecyl sulphate (SDS) into and release from hydrogels composed of the polyelectrolyte poly(methyl vinyl ether-co-maleic acid) crosslinked in a 2:1 ratio with PEG 10,000 were investigated as a potential rapid photodynamic antimicrobial chemotherapy (PACT) treatment for infected wounds using iontophoresis as a novel delivery method. Photosensitiser uptake was very high; (% TMP uptake; 95.53–96.72%) (% MB uptake; 90.58–93.26%) and was PMVE/MA concentration independent, whilst SDS severely limited TMP uptake (5.93–8.75%). Hydrogel hardness, compressibility and adhesiveness on the dermal surface of neonate porcine skin increased with PMVE/MA concentration and were significantly increased with SDS.The ionic conductivities of the hydrogels increased with PMVE/MA concentration. Drug release was PMVE/MA concentration independent, except for drug release under iontophoteric conditions for MB and TMP (without SDS). In just 15 min, the mean% drug concentrations released of TMP, TMP (with SDS) and MB using an electric current ranged from 22.30 to 64.72 μgml−1, 6.37–4.59 μgml−1 and 11.73–36.57 μgml−1 respectively. These concentrations were in excess of those required to induce complete kill of clinical strains of meticillin-resistant Staphylococcus aureus and Burkholderia cepacia. Thus these results support our contention that the iontophoteric delivery of TMP and MB using anti-adherent, electrically-responsive, PEG-crosslinked PMVE/MA hydrogels are a potential option in the rapid PACT treatment of infected wounds.

► Anti-adherent hydrogels were prepared from aqueous polymeric blends. ► These hydrogels are electrically conducting. ► Photosensitisers are rapidly released upon current application. ► Great potential for enhanced patient care exists..

Keywords
Iontophoresis; Poly (methyl vinyl ether-co-maleic acid); Poly (ethylene glycol); Hydrogels; Wound infection; Photodynamic antimicrobial chemotherapy (PACT)
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Electrically-responsive anti-adherent hydrogels for photodynamic antimicrobial chemotherapy
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 114, 3 September 2012, Pages 61–72
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us