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Dental resin curing blue light induced oxidative stress with reactive oxygen species production

Paper ID Volume ID Publish Year Pages File Format Full-Text
30743 44500 2012 6 PDF Available
Title
Dental resin curing blue light induced oxidative stress with reactive oxygen species production
Abstract

Dental resin curing blue light has been used in the treatment of tooth bleaching and to restore teeth with resin-based composite fillings. However, there has been little consideration of its effect on oral tissues such as dental pulp and oral mucosa. The aim of this study was to investigate whether dental resin curing blue light irradiation affects the dental pulp, especially the blood vessels that are known as the first target of reactive oxygen species (ROS), which play an important role in vascular reactivity. We found that blue light irradiation increased the level of lipid peroxidation in isolated rat aorta blood vessels by measuring malondialdehyde. Furthermore, cell proliferative activity was decreased in a time-dependent manner and apoptosis of human aorta vascular smooth muscle cells (VSMCs) was induced. These results indicated that (ROS) such as hydrogen peroxide and hydroxyl radicals were generated in VSMCs by irradiation with blue light, and they induced cytotoxicity associated with oxidative stress, which increased lipid peroxidation and apoptosis. In addition, N-acetyl-l-cysteine, which is a typical intracellular antioxidant, protected VSMCs against cytotoxicity associated with oxidative stress. These findings suggested that antioxidants may be used to prevent oxidative stress in dental pulp by repeated and/or multiple treatments with blue light irradiation in future dental treatments.

► Dental resin curing blue light is generating reactive oxygen species in vascular smooth muscles cells (VSMCs). ► Blue light decrease the proliferative activity and induced the apoptosis on VSMC in a time-dependent manner. ► N-acetyl-l-cysteine is prevented the cytotoxicity with blue light irradiation-induced oxidative stress.

Keywords
Apoptosis; Dental curing blue light; Lipid peroxidation; Antioxidants; Oxidative stress; Vascular smooth muscle cell
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Dental resin curing blue light induced oxidative stress with reactive oxygen species production
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 114, 3 September 2012, Pages 73–78
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us