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Photosensitizer absorption coefficient modeling and necrosis prediction during photodynamic therapy

Paper ID Volume ID Publish Year Pages File Format Full-Text
30744 44500 2012 8 PDF Available
Title
Photosensitizer absorption coefficient modeling and necrosis prediction during photodynamic therapy
Abstract

The development of accurate predictive models for Photodynamic Therapy (PDT) has emerged as a valuable tool to adjust the current therapy dosimetry to get an optimal treatment response, and definitely to establish new personal protocols. Several attempts have been made in this way, although the influence of the photosensitizer depletion on the optical parameters has not been taken into account so far. We present a first approach to predict the spatio-temporal variation of the photosensitizer absorption coefficient during PDT applied to dermatological diseases, taking into account the photobleaching of a topical photosensitizer. This permits us to obtain the photons density absorbed by the photosensitizer molecules as the treatment progresses and to determine necrosis maps to estimate the short term therapeutic effects in the target tissue. The model presented also takes into account an inhomogeneous initial photosensitizer distribution, light propagation in biological media and the evolution of the molecular concentrations of different components involved in the photochemical reactions. The obtained results allow to investigate how the photosensitizer depletion during the photochemical reactions affects light absorption by the photosensitizer molecules as the optical radiation propagates through the target tissue, and estimate the necrotic tumor area progression under different treatment conditions.

► Photosensitizer absorption coefficient spatial variation during PDT is modeled. ► Temporal necrosis maps for a basal cell carcinoma under PDT treatment are obtained. ► First approach to develop new light propagation models specific for PDT. ► Improved approach to estimate PDT response by a predictive model.

Keywords
Photodynamic therapy; Absorption coefficient modeling; Photosensitizer; Skin disease; Skin necrosis
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 114, 3 September 2012, Pages 79–86
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us