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Activity of a cationic carotenoid derivative in a mouse model of protoporphyria

Paper ID Volume ID Publish Year Pages File Format Full-Text
30762 44501 2007 6 PDF Available
Title
Activity of a cationic carotenoid derivative in a mouse model of protoporphyria
Abstract

Prior work using cell culture has shown that certain synthetic carotenoid derivatives are more effective than natural carotenoids in preventing photosensitized cell killing. These carotenoid derivatives are either cationic or are weak bases. We have now found that of one of these derivatives, the Girard’s reagent T derivative of β-apo-8′-carotenal (GRT-carotenal) decreases acute photosensitivity in a mouse model of protoporphyria. When GRT-carotenal was added to the diet of SKH1 mice, both GRT-carotenal and its metabolites accumulated in the skin of the mice. Protoporphyria was induced in SKH1 mice by adding collidine to their diet. When the porphyric mice were exposed to 400 nm light (2.6 ± 0.1 mW cm−2) for a period of 2 h, the skin on the backs of these animals increased in thickness. Increased vascularity also developed in the skin of the mouse ears. Animals, that were fed a diet containing both collidine and GRT-carotenal and then exposed to light, had significantly smaller increases in skin thickness and less prominent increases in the vascular pattern on their ears.

Keywords
Cationic carotenoid derivative; Protoporphyria; Photosensitivity
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Activity of a cationic carotenoid derivative in a mouse model of protoporphyria
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 87, Issue 2, 25 May 2007, Pages 124–129
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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