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The use of photosensitisers in acne treatment

Paper ID Volume ID Publish Year Pages File Format Full-Text
30766 44502 2011 5 PDF Available
Title
The use of photosensitisers in acne treatment
Abstract

Whereas the standard approach to the treatment of acne vulgaris has involved both systemic and topical antibiotics and topical agents such as benzoyl peroxide, problems exist due to side effects, drug resistance and lack of compliance. The photoantimicrobial approach offers a rapid treatment for large areas of afflicted dermis, based on the generation of reactive oxygen species in situ. Various chemical types are available as a topical modality, both in respect of the photosensitising agent and the activating light source, the suggested therapeutic approach requiring medical supervision. Due to a novel mode of action, the use of photosensitisers constitutes a convenient option against drug-resistant bacteria.

► Review of the potential of photoantimicrobials in the treatment of acne vulgaris. ► Comparisons of established and new photosensitisers/precursors. ► New phenothiazinium derivative is considerably more effective in vitro than methylene blue.

Keywords
Acne vulgaris; Aminolaevulinic acid; Methylene blue; Photodynamic antimicrobial chemotherapy; Photosensitisers
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 105, Issue 1, 5 October 2011, Pages 1–5
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
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Price was $35.95
You save - $31
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