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Synthesis, single-crystal characterization, antimicrobial activity and remarkable in vitro DNA interaction of hydrogen-bonded proton-transfer complex of 1,10-phenanthroline with 2,4,6-trinitrophenol

Paper ID Volume ID Publish Year Pages File Format Full-Text
30767 44502 2011 8 PDF Available
Title
Synthesis, single-crystal characterization, antimicrobial activity and remarkable in vitro DNA interaction of hydrogen-bonded proton-transfer complex of 1,10-phenanthroline with 2,4,6-trinitrophenol
Abstract

A new charge transfer complex as a result of interaction between 1,10-phenanthroline (donor) with 2,4,6-trinitrophenol (picric acid), acceptor, was synthesized and characterized by FTIR, 1H NMR, 13C NMR, mass spectroscopy, single-crystal X-ray diffraction and elemental analysis. The single crystal structure indicates that the cation and anion are joined together by strong N+H⋯O− type hydrogen bonds. This has been attributed to the formation of 1:1 CT complex via hydrogen bonding interaction. The binding of CT complex with in vitro calf thymus DNA was investigated by the fluorescence spectroscopy. To determine the DNA binding ability of the compound, fluorescence intensity data were analyzed by the Stern–Volmer equation and remarkable DNA interaction with CT complex is found. The CT complex was also screened for its antimicrobial activity. The CT complex exhibited inhibitory results against E. coli and Pseudomonas arenginosa, and the marked enhancement in the potency as antifungal agent.

Graphical abstractFluorescence emission spectra of CT complex in the absence (—) and presence of increasing amount of DNA from top second spectra to bottom.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► In this article, we report the formation of newly hydrogen-bonded charge transfer complex. ► We characterize hydrogen-bonded charge transfer complex. ► The crystal structure CT complex determined by single-crystal X-ray diffraction. ► We examine the DNA-binding studies of CT complex. ► The CT complex is also screened for its antifungal and antibacterial activity.

Keywords
1,10-Phenanthroline; Proton transfer; Single X-ray crystallography; 1H NMR; Pharmacology
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Synthesis, single-crystal characterization, antimicrobial activity and remarkable in vitro DNA interaction of hydrogen-bonded proton-transfer complex of 1,10-phenanthroline with 2,4,6-trinitrophenol
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 105, Issue 1, 5 October 2011, Pages 6–13
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us