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Fluorescence properties and antiproliferative effects of mono-, bis-, and tris- thiophenylnaphthalimides: Results of a comparative pilot study

Paper ID Volume ID Publish Year Pages File Format Full-Text
30776 44502 2011 6 PDF Available
Title
Fluorescence properties and antiproliferative effects of mono-, bis-, and tris- thiophenylnaphthalimides: Results of a comparative pilot study
Abstract

A series of mono-, bis- and trisnaphthalimides with different substituents on the naphthalimide ring system was prepared. For compounds containing a thiophenyl substituent fluorescence spectroscopic measurements were performed and unexpectedly showed an increase in fluorescence emission for the bis- and trisnaphthalimide derivatives in phosphate buffered saline. Additional fluorescence microscopic experiments indicated an efficient cellular uptake of the thiophenyl substituted compound 1c into cultured tumor cells. Experiments on the inhibition of tumor cell proliferation were performed in MCF-7 breast adenocarcinoma and HT-29 colon carcinoma cells and confirmed derivatives containing a nitro substituent as the most active compounds. Compound 1c demonstrated potential as photoinducable antitumor agent.

Graphical abstractA series of mono-, bis-, and tris-naphthalimides was studied for fluorescence emission properties, biodistribution and antiproliferative effects in tumor cells.Figure optionsDownload full-size imageDownload as PowerPoint slideHighlights► Naphthalimides with thiophenyl substituents display environmental sensitive fluorescence emission. ► 1,8-Naphthalimides are prospective antitumor drugs. ► Antiproliferative effects can be enhanced by photoirradiation.

Keywords
Naphthalimides; Antitumor drugs; Photoinduced electron transfer
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Fluorescence properties and antiproliferative effects of mono-, bis-, and tris- thiophenylnaphthalimides: Results of a comparative pilot study
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 105, Issue 1, 5 October 2011, Pages 75–80
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us