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Inactivation of vascular smooth muscle cells photosensitised by liposome-delivered Zn(II)–phthalocyanine

Paper ID Volume ID Publish Year Pages File Format Full-Text
30803 44504 2006 6 PDF Available
Title
Inactivation of vascular smooth muscle cells photosensitised by liposome-delivered Zn(II)–phthalocyanine
Abstract

Photodynamic therapy is a promising approach for the prevention of arterial restenosis, which frequently occurs after balloon angioplasty, largely owing to abnormal proliferation of vascular smooth muscle cells (VSMC) and their migration from the media to the intima, where they originate intimal hyperplasia (IH). We investigated the efficacy of Zn(II)–phthalocyanine-photosensitised processes in promoting the inactivation of VSMC. This liposome delivered phthalocyanine is readily taken up by VSMC, largely partitions in the Golgi apparatus, and upon photoactivation causes >95% cell mortality using mild irradiation conditions (e.g. 5 min irradiation at 1 μM ZnPc). Cell death occurs through the parallel development of random necrotic and apoptotic processes.

Keywords
Intimal hyperplasia; Smooth muscle cells; Photodynamic therapy; Photosensitisation; Phthalocyanines
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Inactivation of vascular smooth muscle cells photosensitised by liposome-delivered Zn(II)–phthalocyanine
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 82, Issue 1, 2 January 2006, Pages 53–58
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us