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Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition

Paper ID Volume ID Publish Year Pages File Format Full-Text
30873 44511 2006 7 PDF Available
Title
Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition
Abstract

In this report, we demonstrate a possible molecular mechanism by which a hydrophilic extract of the leaves of the fern Polypodium leucotomos (Fernblock®, PL) blocks ultraviolet (UV)-induced skin photodamage. The extract inhibits UVA and UVB light induced photoisomerization of trans-urocanic acid (t-UCA), a common photoreceptor located in the stratum corneum, and also blocks its photodecomposition in the presence of oxidizing reagents such as H2O2, and titanium dioxide (TiO2). PL protects in vitro human fibroblasts from UV-induced death as well. These results suggest the potential of employing the PL extract as a component of sunscreen moistures in order to prevent photodecomposition of t-UCA, to inhibit UV-induced deleterious effects of TiO2 and to protect skin cells and endogenous molecules directly involved in skin immunosurveillance.

Keywords
Polypodium; Urocanic acid; Photoisomerization; Titanium dioxide; H2O2; Ultraviolet radiation
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Polypodium leucotomos extract inhibits trans-urocanic acid photoisomerization and photodecomposition
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 82, Issue 3, 1 March 2006, Pages 173–179
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us