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Synthesis and photo-induced DNA cleaving activities of conjugates of halophenyl derivative and polyamide containing N-methylimidazoles

Paper ID Volume ID Publish Year Pages File Format Full-Text
30875 44511 2006 7 PDF Available
Title
Synthesis and photo-induced DNA cleaving activities of conjugates of halophenyl derivative and polyamide containing N-methylimidazoles
Abstract

Halophenyl derivatives were linked to different termini of polyamide containing three imidazole rings to give novel conjugates for examining the influence of the location of linking on DNA-cleavage efficiency. The DNA cleavage activities of the conjugates were compared on supercoiled DNA (pBluescript SK) under UV irradiation at 365 nm. It was found that bromophenyl-ImImImβDp (2), which is the conjugate of bromophenyl motif directly linked to the N-terminus of polyamide, had the highest photocleavage efficiency among six novel conjugates. In addition, it was found that the polyamide containing three N-methylimidazole rings could greatly enhance the photocleavage efficiency of these conjugates.

Keywords
DNA-photocleavage agents; pSK DNA; Conjugate; Halophenyl derivative; Polyamide
First Page Preview
Synthesis and photo-induced DNA cleaving activities of conjugates of halophenyl derivative and polyamide containing N-methylimidazoles
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 82, Issue 3, 1 March 2006, Pages 187–193
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering