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Low-intensity red laser on the prevention and treatment of induced-oral mucositis in hamsters

Paper ID Volume ID Publish Year Pages File Format Full-Text
30902 44513 2009 7 PDF Available
Title
Low-intensity red laser on the prevention and treatment of induced-oral mucositis in hamsters
Abstract

ObjectiveThe purpose of this study was to investigate the effects of laser phototherapy as preventive and therapeutic regime on induced-oral mucositis in hamsters.DesignThe animals were divided into four groups: preventive cryotherapy, preventive laser, therapeutic laser and therapeutic control group. Mucositis was induced in hamsters by intraperitoneal injection of 5-fluorouracil (5-FU) and superficial scratching. All preventive treatment was performed on the right cheek pouch mucosa. The left pouch mucosa was used for a spontaneous development of mucositis and did not receive any preventive therapy. Laser parameters were: λ = 660 nm, P = 30 mW, D = 1.2 J/cm2, Δt = 40 s, spot size 3 mm2, I = 1 W/cm2. Cryotherapy was done positioning ice packs in the hamster mucosa 5 min before 5-FU infusion and 10 min afterward. To study the healing of mucositis, the left pouch mucosa of each of the hamsters in the TLG received laser irradiation on the injured area. Irradiation parameters were kept the same as abovementioned. The control hamsters in the TCG did not receive any treatment. The mucositis degree and the animal’s body mass were evaluated. An assessment of blood vessels was made based on immunohistochemical staining.ResultsThe CG animals lost 15.16% of theirs initial body mass while the LG animals lost 8.97% during the first 5 days. The laser treated animals had a better clinical outcome with a faster healing, and more granulation tissue. The quantity of blood vessels at both LG and CG were higher than in healthy mucosa. Regarding the therapeutic analysis, the severity of the mucositis in the TLG was always lower than TCG. TLG presented higher organization of the granulation tissue, parallel collagen fibrils, and increased angiogenesis.ConclusionThe results suggest that laser phototherapy had a positive effect in reducing mucositis severity, and a more pronounced effect in treating established mucositis.

Keywords
Cancer; Chemotherapy; Cryotherapy; Radiotherapy; Ulcer
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Low-intensity red laser on the prevention and treatment of induced-oral mucositis in hamsters
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 94, Issue 1, 9 January 2009, Pages 25–31
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us