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Photosensitized xanthone-based oxidation of guanine and its repair: A laser flash photolysis study

Paper ID Volume ID Publish Year Pages File Format Full-Text
30918 44514 2011 5 PDF Available
Title
Photosensitized xanthone-based oxidation of guanine and its repair: A laser flash photolysis study
Abstract

The photosensitized oxidation of guanine (G) by the triplet state of xanthone (XT) and the repair for photo-damaged G(–H) by ferulic acid (FCA) were investigated using the laser flash photolysis technique. The rate constants of the reaction of triplet state of XT with G and with FCA were determined as 4.5 × 109 and 8.0 × 109 L mol−1 s−1, respectively. Laser exposure was performed on the N2-saturated acetonitrile/water (v/v, 1:1) solution containing G, XT and FCA. The transient absorption spectra indicated that the triplet state of XT first reacted with G predominantly to form the oxidized radical G(–H). The radical G(–H) was rapidly repaired by FCA, and the rate constant for the repair reaction was determined as 1.1 × 109 L mol−1 s−1. These results demonstrated that non-enzymatic repair is a feasible method for repairing photosensitized DNA bases oxidation.

► The triplet state of xanthone (XT) reacted with guanine (G) by hydrogen transfer. ► The triplet state of xanthone (XT) reacted with ferulic acid (FCA) by electron transfer. ► The triplet state of XT first reacted with G to form the oxidized radical G(–H), which were then fast repaired by FCA.

Keywords
Xanthone; Guanine; Ferulic acid; Fast repair; DNA damage; Laser flash photolysis
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Photosensitized xanthone-based oxidation of guanine and its repair: A laser flash photolysis study
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 105, Issue 2, 3 November 2011, Pages 157–161
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
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Any Questions? feel free to contact us