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Antibacterial activity of anthraquinone derivatives from Heterophyllaea pustulata (Rubiaceae)

Paper ID Volume ID Publish Year Pages File Format Full-Text
30934 44518 2011 7 PDF Available
Title
Antibacterial activity of anthraquinone derivatives from Heterophyllaea pustulata (Rubiaceae)
Abstract

Photosensitizing anthraquinones isolated from Heterophyllaea pustulata Hook f. (Rubiaceae), namely soranjidiol, rubiadin, damnacanthal and 5,5′-bisoranjidiol, showed antibacterial activity (bacteriostatic/bactericide) on Staphylococcus aureus.   The mechanism of action seems to involve an increase in the levels of superoxide anion (O2−) and/or singlet molecular oxygen (1O2). Moreover, the effect of actinic irradiation as a boosting agent for the production of both reactive species of oxygen as well as its influence on antibacterial activity was assessed. The routine susceptibility assay (minimum inhibitory concentration determination) was carried out by means of the broth macrodilution method. Bactericide activity was determined counting the colony-forming units per milliliter (cfu/mL) in plate. The O2− production was determined by means of an indirect photobiological assay (Nitroblue Tetrazolium test), and the production of 1O2 was followed using an indirect steady-state method, with methionine as the 1O2 chemical quencher.

Keywords
Heterophyllaea pustulata; Anthraquinones; Antibacterial activity; Staphylococcus aureus; Photosensitizers; Reactive oxygen species
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Antibacterial activity of anthraquinone derivatives from Heterophyllaea pustulata (Rubiaceae)
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 102, Issue 2, 7 February 2011, Pages 108–114
Authors
, , , , , ,
Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
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