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Protective effects of κ-ca3000 + CP against ultraviolet-induced damage in HaCaT and MEF cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
30961 44522 2010 9 PDF Available
Title
Protective effects of κ-ca3000 + CP against ultraviolet-induced damage in HaCaT and MEF cells
Abstract

In this study, the complex κ-ca3000 + CP combined collagen peptide with κ-carrageenan oligosaccharide was tested for its ability to moderate UV-induced damage and investigated for its protective mechanism against UV radiation. Human keratinocytes (HaCaT) and mouse embryonic fibroblasts (MEF) were used to monitor the effects of κ-ca3000 + CP on cell viability, apoptosis, level of collagen I and MMP-1, MAPKs activation and intracellular ROS production after UV-irradiation. The results indicated that application of the κ-ca3000 + CP (100 μg/ml) could significantly attenuate UV-induced HaCaT and MEF death, as well as inhibit the UV-induced apoptosis of HaCaT cells. The decreased collagen I synthesis and the increased MMP-1 expression of MEF by UV radiation were almost restored back to normal level after treatment with κ-ca3000 + CP. Moreover, κ-ca3000 + CP could significantly suppress UV-induced MAPKs activation and intracellular ROS production. Taken together, these results showed that antioxidant property of κ-ca3000 + CP can effectively attenuate UV-caused cell damage and skin photoaging by suppressing cell apoptosis and expression of MMP-1 through the MAPKs signaling pathways. Thus, κ-ca3000 + CP has potential antiaging effects and prominent protective effects on UV-induced skin cell damages, which might be used in pharmaceutical and cosmetic industries.

Keywords
Peptide–oligosaccharide complex; Antioxidant; Photoprotection; UV-irradiation
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Protective effects of κ-ca3000 + CP against ultraviolet-induced damage in HaCaT and MEF cells
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Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 101, Issue 1, 5 October 2010, Pages 22–30
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering
Get Full-Text Now
Don't Miss Today's Special Offer
Price was $35.95
You save - $31
Price after discount Only $4.95
100% Money Back Guarantee
Full-text PDF Download
Online Support
Any Questions? feel free to contact us