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Prooxidant and antioxidant behaviour of usnic acid from lichens under UVB-light irradiation – Studies on human cells

Paper ID Volume ID Publish Year Pages File Format Full-Text
30970 44522 2010 6 PDF Available
Title
Prooxidant and antioxidant behaviour of usnic acid from lichens under UVB-light irradiation – Studies on human cells
Abstract

Natural compounds which can behave as antioxidants and protect against UV-radiation may well have medical and cosmetic value. Usnic acid, which can be obtained from lichens offer such a potential. The latter is one of the best known and reviewed compounds present in lichens and exhibits many properties of value such as antibiotic, antitumor and UV-filter-effects. We report studies of the potential antioxidant and prooxidant activity of usnic acid extracted from Xanthoparmelia farinosa (Vainio) using a human lymphocyte cell line (Jurkat-cells) under UV-B-irradiation. Cell survival and cell metabolism were determined using different conditions such as usnic acid concentration and UVB dose. Compared to the controls the cells incubated with usnic acid in concentrations of 1 × 10−8 and 1 × 10−6 M showed a higher cell survival and a normal metabolism under low doses of UVB-light up to 0.1 J/cm2. When both higher UVB doses (up to 14 J/cm2) and higher concentrations of usnic acid (1 × 10−4 M) where used, the opposite effect was observed. It is concluded that these effects are due to bifunctional (a switch of) anti-oxidative–pro-oxidative behaviour of usnic acid under UV-B-irradiation.

Keywords
Lichens; Usnic acid; Antioxidant; Prooxidant; UV-B-irradiation; Human lymphoid cells
First Page Preview
Prooxidant and antioxidant behaviour of usnic acid from lichens under UVB-light irradiation – Studies on human cells
Publisher
Database: Elsevier - ScienceDirect
Journal: Journal of Photochemistry and Photobiology B: Biology - Volume 101, Issue 1, 5 October 2010, Pages 97–102
Authors
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Subjects
Physical Sciences and Engineering Chemical Engineering Bioengineering